The neuroinflammatory response of postoperative cognitive decline

The neuroinflammatory response of postoperative cognitive decline.

BACKGROUND Aseptic surgical trauma provokes a homeostatic neuroinflammatory response to promote healing and protect the organism from further injury. When this response is dysregulated, harmful consequences can follow, including postoperative cognitive decline. SOURCES OF DATA We performed a comprehensive search on PubMed related to postoperative cognitive dysfunction (POCD). AREAS OF AGREE...

Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats.

To investigate the role of the pro-inflammatory cytokine interleukin-1β (IL-1β) in postoperative cognitive dysfunction (POCD) in aged rats, we used laparotomy to mimic human abdominal surgery in adult (3 months) and aged (24 months) F344/BN rats. We demonstrated that memory consolidation of the hippocampal-dependent contextual fear-conditioning task is significantly impaired in aged but not you...

Postoperative cognitive decline: where art tau?

T AU is an axonal microtubule-associated protein whose best known function is to bind and stabilize microtubules and promote their polymerization. Tau, a variously sized protein, has a number of repeated domains that bind tubulin and a number of phosphorylation sites that modulate its affinity for tubulin. In general, phosphorylation through a number of kinases decreases tau affinity to microtu...

Is postoperative cognitive decline clinically relevant?

To the Editor: We applaud Avidan et al. in their assessment of the general relationship between postoperative cognitive dysfunction (POCD) and dementing illness. We have a number of questions and concerns, and we hope the authors might address them. As noted by the authors, the report revisits the question of whether geriatric patients who undergo surgery have a more rapid decline into dementia...

Does Anesthesia Cause Postoperative Cognitive Decline?